Clinical Characteristics of Patients with Acquired Resistance to PD-1 Directed Therapies

Sarmen Sarkissian, MD

In this recent publication in JTO, Gettinger et al. report on the characteristics of patients that had progression on PD-1 directed therapies. The authors showed that for patients that had progression at a limited number of sites had durable responses after local therapy such as radiotherapy was employed. Studies such as these are quite useful as it allows for maximizing of systemic benefits while managing local progression. It underscores the value of addressing tumor heterogeneity in clinical practice.  

https://www.jto.org/article/S1556-0864(18)30210-7/fulltext

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